Cyanoacetic acid ethyl ester
Ethyl cyanoacetate
CAS: 105-56-6
Molecular Formula: C5H7NO2
Cyanoacetic acid ethyl ester - Names and Identifiers
| Name | Ethyl cyanoacetate |
| Synonyms | ETHYLE CYANACETATE Ethyl cyanoacetate Cyanoacetic acid ethyl ester |
| CAS | 105-56-6 |
| EINECS | 203-309-0 |
| InChI | InChI:1S/C5H7NO2/c1-2-8-5(7)3-4-6/h2-3H2,1H3 |
Cyanoacetic acid ethyl ester - Physico-chemical Properties
| Molecular Formula | C5H7NO2 |
| Molar Mass | 113.115 |
| Density | 1.047g/cm3 |
| Melting Point | -22℃ |
| Boling Point | 203.6°C at 760 mmHg |
| Flash Point | 84.1°C |
| Water Solubility | 20 g/L (20℃) |
| Vapor Presure | 0.275mmHg at 25°C |
| Refractive Index | 1.412 |
| Physical and Chemical Properties | Characteristics of colorless or yellowish liquid. Aromatic odor. melting point -22.5 ℃ boiling point 208~210 ℃ relative density 1.0560 refractive index 1.4175 flash point 110 ℃ solubility insoluble in water. Miscible with ethanol and ether. Soluble in aqueous ammonia, strong alkali solution. |
| Use | Used as a pharmaceutical intermediate, for caffeine and vitamin B, but also for oil-soluble couplers for color films and raw materials for 502 adhesives |
Cyanoacetic acid ethyl ester - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 2666 |
Cyanoacetic acid ethyl ester - Upstream Downstream Industry
| Raw Materials | Sulfuric acid Chloroacetic acid Sodium cyanide Hydrochloric acid Chloroacetic acid Ethyl Alcohol |
| Downstream Products | dacarbazine Nifedipine amiloride hydrochloride hydrate |
Cyanoacetic acid ethyl ester - Nature
Open Data Verified Data
colorless or yellowish liquid. Aromatic odor. The relative density was 1. 0560. Melting Point -22.5 °c. Boiling point 208~210 deg C. Refractive index 4175. Flash point 110 °c. Insoluble in water. Miscible with ethanol and ether. Soluble in aqueous ammonia, strong alkali solution.
Last Update：2024-01-02 23:10:35
Cyanoacetic acid ethyl ester - Preparation Method
Open Data Verified Data
- chloroacetic acid esterification cyanation method esterification of chloroacetic acid and ethanol to generate ethyl chloroacetate, the refined ethyl chloroacetate and sodium cyanide were cyanated to prepare the crude ethyl cyanoacetate, which was then filtered, high quality ethyl cyanoacetate can be obtained by frequent pressure distillation and vacuum distillation.
- chloroacetic acid cyanation esterification method to generate chloroacetic acid with soda ash neutralization of sodium chloroacetate, and then with sodium cyanide to sodium cyanoacetate, then with hydrochloric acid to obtain cyanoacetic acid, and finally with ethanol esterification to obtain ethyl cyanoacetate, after filtration, atmospheric distillation, vacuum distillation to obtain the finished product.
- cyanoacetic acid esterification method cyanoacetic acid was esterified with ethanol.
Last Update：2022-01-01 10:37:09
Cyanoacetic acid ethyl ester - Use
Open Data Verified Data
raw materials for organic synthesis. It is used as an intermediate in the synthesis of caffeine and vitamin B6 in medicine. It is also used as a raw material and analytical reagent for color film oil soluble couplers and synthetic adhesives.
Last Update：2022-01-01 10:37:09
Cyanoacetic acid ethyl ester - Safety
Open Data Verified Data
- This product is highly toxic. Poisoning is caused primarily by ingestion or absorption from the skin. Rat oral LD50400 ~ 3200mg/kg. Guinea pig percutaneous LD50 >5mL/kg. Its toxicity and protection method see cyanoacetic acid.
- This product is sealed and packaged in aluminum barrels with a net weight of 200kg per barrel. Storage and Transportation to moisture, sun protection, fire. Hazardous materials shall be stored and transported according to regulations.
Last Update：2022-01-01 10:37:10
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Raw Materials for Cyanoacetic acid ethyl ester
Downstream Products for Cyanoacetic acid ethyl ester